• Before 1215: Establishment of the Monastery of Mother of God of Oxia Episkepsis [Accute Visitation] of Makrinitissa, by the Local Lord of Demetrias, Konstantinos Melissenos.
  • 1215: Recognition of the stavropigian value of the Monastery, directly under the authority of the Ecumenical Patriarchate.
  • 1223 to 1275: Consecutive ratifications of the stavropigian regime of the Monastery by the publication of patriarchal documents.
  • 1246 to 1279: Consecutive ratifications of the significant property of the Monastery by the publication of official documents.
  • After 1246: Founder Constantine Melissenos dwells as monk Konstantios at the Holy Monastery until his death.
  • Before 1260: Nikolaos Melissenos, son of founder Constantine Melissenos, takes over the supervision of the Monastery.
  • 1274: Nikolaos Melissenos becomes a monk and under the name Ioasaf retires to the Holy Monastery of Saint John the Baptist of Nea Petra. His son John Melissenos is appointed Supervisor of the Monasteries of Makrinitissa and Saint John the Baptist of Nea Petra.
  • 1277 to 1279: The Monastery of the Savior (Latomou) in Thessaloniki is assigned to the Monasteries of Makrinitissa and Saint John the Baptist of Nea Petra.
  • 1282 to 1286: The rights and property of the Holy Monastery of Makrinitissa are confirmed anew with imperial and patriarchal documents.
  • Late 13th - early 14th century: John Melissenos renovates the Monastery of Makrinitissa, dwells and is probably buried in it as monk Nilos and second founder.
  • 14th to 17th centuries: The Byzantine Monastery of Makrinitissa falls into decline and becomes obscure. Historic sources are silent.
  • After 1700: Its buildings, probably among them the Katholikon, are destroyed by landslide.
  • 1743: Reconstructed, southwest of today's Holy Church of The Assumption of the Virgin Mary, the two-storey building of the Chapels of Saint Nicholas (ground floor) and of All Saints (first floor).
  • 1767: Reconstructed, the Holy Church of The Assumption of Virgin Mary on the site of the Katholikon of the Byzantine Monastery.
  • Before 1778: There are references to the existence of a bi-component Chapel of Saint Anargiri and Saint Anthony northeastern of the Holy Church of the Assumption of Virgin Mary.
  • 1798: North of the Holy Church of The Assumption of Virgin Mary the Chapel of Saint Magdalene is built.
  • 1815: Northwest of the Holy Church of The Assumption of Virgin Mary, the building of the Metropolis, for the hospitality of any Metropolitan of Demetrias is built.
  • After 1850: Many ecclesiastical heirlooms are recorded - tributes from settlers originating from Makrinitsa, in Odessa Russia; Romania; Egypt.
  • 1955: The post-Byzantine Holy Church of The Assumption of Virgin Mary suffers extensive destruction due to earthquakes, with the exception its east and south sides.
  • 1963: The present Holy Church of The Assumption of Virgin Mary is rebuilt, preserving the original dimensions of the post-Byzantine Church of 1767 and unalterable its typological and morphological characteristics.